Which medications in the drug class Antidepressants, dopamine reuptake inhibitors; opioid antagonists are used in the treatment of Obesity?

Updated: Jun 09, 2021
  • Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Antidepressants, dopamine reuptake inhibitors; opioid antagonists

These agents may cause a reduction in appetite and increase in energy expenditure by increasing activity of pro-opiomelanocortin (POMC) neurons.

Bupropion and naltrexone (Contrave)

Bupropion: Increases dopamine activity in the brain, which appears to lead to a reduction in appetite and increase in energy expenditure by increasing activity of pro-opiomelanocortin (POMC) neurons

Naltrexone: Blocks opioid receptors on the POMC neurons, preventing feedback inhibition of these neurons and further increasing POMC activity

Combination may regulate activity in the dopamine reward system of the brain that helps control food cravings and overeating behaviors


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