Are peptide YY (3-36), leptin, and tagatose approved for the treatment of obesity?

Updated: Jun 09, 2021
  • Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Peptide YY (3-36) is being developed as a nasal inhaler. Ongoing, preliminary phase 1 and 2 trials yielded encouraging results. [175, 176, 177]

Leptin is still used in cases of the rare obesity subclass of leptin-deficient obesity and lipodystrophy, but a study of the leptin analogue metreleptin in obese patients with diabetes found that metreleptin did not alter body weight. [178] The combination of metreleptin with pramlintide, however, led to enhanced weight loss in one study, [179] but a more recent randomized clinical trial on the combination of these 2 drugs was stopped because of safety concerns. [180]

Preliminary reports suggest the potential utility of agents that impede dietary carbohydrate absorption. Tagatose is one of the compounds in this class that is undergoing trials.


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