Why are long-term strategies needed to prevent obesity relapse?

Updated: Jun 09, 2021
  • Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Diet-induced weight loss can result in elevated levels of hormones that increase appetite. After successful weight loss, circulating levels of these hormones do not decrease to levels recorded before diet-induced weight loss. Thus, long-term strategies are needed to prevent obesity relapse. [121]

Contrary to the original belief, however, weight loss after nonsurgical intervention can be maintained long-term. A study by Hamdy et al showed that patients with diabetes and obesity can maintain an average of 6.4% weight loss after 5 years of intensive lifestyle changes in real-world clinical practice. This study also found that patients who maintain 7% or greater weight loss after a year are more likely to maintain weight loss over the long-term. [122]


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