Are there monogenic variants of obesity?

Updated: Jun 09, 2021
  • Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

More than 90% of human cases of obesity are thought to be multifactorial. Nevertheless, the recognition of monogenic variants has greatly enhanced knowledge of the etiopathogenesis of obesity. [78] As previously mentioned, Friedman and colleagues discovered leptin (from the Greek word leptos, meaning thin) in 1994 and ushered in an explosion of research and a great increase in knowledge about regulation of the human feeding and satiation cycle.


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