Does elevated intra-abdominal pressure in obesity increase the risk of comorbidity?

Updated: Jun 09, 2021
  • Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Apart from the metabolic complications associated with obesity, a paradigm of increased intra-abdominal pressure has been recognized. This pressure effect is most apparent in the setting of marked obesity (BMI ≥ 50 kg/m2) and is espoused by bariatric surgeons. [24]

Findings from bariatric surgery and animal models suggest that this pressure elevation may play a role (potentially a major one) in the pathogenesis of comorbidities of obesity, such as the following [25] :

  • Pseudotumor cerebri

  • Lower-limb circulatory stasis

  • Ulcers

  • Dermatitis

  • Thrombophlebitis

  • Reflux esophagitis

  • Abdominal hernias

  • Possibly, hypertension and nephrotic syndrome


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