Which second-order neuron lesions cause Horner syndrome?

Updated: May 01, 2019
  • Author: Christopher M Bardorf, MD, MS; Chief Editor: Edsel Ing, MD, MPH, FRCSC  more...
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Second-order neuron lesions that may give rise to Horner syndrome include the following:

  • Pancoast tumor (tumor in the apex of the lung, most commonly squamous cell carcinoma)

  • Birth trauma with injury to lower brachial plexus [7]

  • Cervical rib

  • Aneurysm or dissection of the aorta

  • Lesions of the subclavian or common carotid artery

  • Central venous catheterization

  • Trauma or surgical injury (eg, due to radical neck dissection, thyroidectomy, [8] carotid angiography, radiofrequency tonsil ablation, [9] chiropractic manipulation, [10] or coronary artery bypass grafting)

  • Chest tubes

  • Lymphadenopathy (eg, Hodgkin disease, leukemia, tuberculosis, or mediastinal tumors)

  • Mandibular tooth abscess

  • Lesions of the middle ear (eg, acute otitis media)

  • Neuroblastoma [11]

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