What is included in the long-term monitoring of ocular lymphoma?

Updated: Mar 15, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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Despite usually demonstrating an indolent course, extranodal marginal zone B-cell lymphomas are renowned for recurrence in extranodal sites, including other ocular adnexal sites. [41] These sites can also include the lung, parotid gland, and bone marrow. [48]

Close clinical follow-up every 6 months for 2 years upon completion of treatment and annually thereafter is recommended. The evaluation should include neuroimaging studies (eg, ultrasonography, computed tomography [CT], or magnetic resonance imaging [MRI] of the orbits) to look for residual or recurrent local disease.

Serial imaging can be a very useful tool for detecting recurrence. Residual fibrosis of involved extraocular muscles or other orbital structures can appear similar to tumor. Whether re-biopsy or exploration is indicated should be a clinical decision, often aided by serial imaging.

A clinical oncologist should also follow up with the patient for a thorough systemic evaluation every 6 months for 2 years and annually thereafter.

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