What is the role of orbital biopsy in the workup of ocular lymphoma?

Updated: Mar 15, 2019
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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Biopsy of the lesion is essential to confirm the diagnosis and also to help grade the lymphoma. The diffuse infiltrating nature of lymphomas may make their complete excision difficult. Also, their excellent response to irradiation obviates the need for complete excision.

The route of biopsy is chosen depending on the site of the lesion. Direct approach is possible for conjunctival and lid lesions, whereas orbitotomy is needed for lesions involving the lacrimal gland or posterior orbit. In the case of bilateral disease, only 1 orbit need undergo biopsy.

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