Which histologic findings are characteristic of iris melanoma?

Updated: Jul 13, 2021
  • Author: Buraa Kubaisi, MD, FICO, MRCS(Edin); Chief Editor: Michael Taravella, MD  more...
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Malignant melanocytic stromal proliferation disrupts the normal iris stromal architecture. The Callender classification divides iris melanomas into spindle A (benign) and spindle B (fascicular, mixed, epithelioid, and necrotic) types. The Jakobiec and Silbert classification categorizes the lesions as spindle cell melanoma, spindle and epithelioid melanoma, or epithelioid melanoma. [17] According to a modified Callender classification system, most reported iris melanomas in the literature are diagnosed as spindle cell melanoma. [18]

Small and unifocal melanomas are commonly associated with a spindle cell histopathology. [19]

There is evidence that the proliferation of melanocytes of the anterior iris surface and diffuse stromal invasion may be risk factors for local recurrence and metastasis. [20]

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