What causes iris melanoma?

Updated: Jul 13, 2021
  • Author: Buraa Kubaisi, MD, FICO, MRCS(Edin); Chief Editor: Michael Taravella, MD  more...
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Most iris melanomas are believed to arise from a preexisting nevi. Epidemiologic studies suggest that high levels of solar ultraviolet B (UV-B) radiation plays a role in the pathogenesis of iris melanomas. [2] Loss of chromosome 3, as well as loss of chromosomal region 9p21 (entails tumor suppressor gene CDKN2A), plays a role in iris melanoma. [3]

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