How is human leukocyte antigen (HLA) B27–associated reactive arthritis diagnosed?

Updated: Apr 09, 2021
  • Author: Huy D Nguyen, MD, MBA; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Reactive arthritis is a clinical diagnosis without definitive laboratory or radiographic findings. The diagnosis should be considered when an acute asymmetric inflammatory arthritis or tendonitis follows an episode of diarrhea or dysuria. These diseases are also spondyloarthropathies involving the tendon insertion, not the synovium, primarily of weightbearing joints. HLA-B27 testing is not essential to confirm the diagnosis, but it may determine the eventual severity and chronicity of the condition. [30]

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