How is a human leukocyte antigen (HLA) disease association defined?

Updated: Apr 09, 2021
  • Author: Huy D Nguyen, MD, MBA; Chief Editor: Andrew A Dahl, MD, FACS  more...
  • Print
Answer

Answer

An HLA disease association is defined as a statistically increased frequency of the HLA haplotype in individuals with the specific disease compared to the frequency in individuals without the disease. This is expressed as a relative risk. For example, 80-90% of patients with ankylosing spondylitis have HLA-B27. Expressed as a relative risk, an HLA-B27 positive individual is approximately 87 times more susceptible to developing ankylosing spondylitis compared to the general population.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!