Which conditions are associated with HLA-B27?

Updated: Apr 09, 2021
  • Author: Huy D Nguyen, MD, MBA; Chief Editor: Andrew A Dahl, MD, FACS  more...
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The first human leukocyte antigen (HLA) haplotype association with human inflammatory disease was discovered in 1972, correlating HLA-B27 with ankylosing spondylitis. This remains one of the strongest known associations of this disease with HLA-B27. Since then, more than 100 disease associations have been made, including many exclusively ocular diseases and also systemic diseases with specific ocular manifestations.1 The most notable conditions among these include: ankylosing spondylitis, reactive arthritis (previously referred to as Reiter syndrome), Behçet's disease, inflammatory bowel disease, and psoriatic arthritis. These conditions fall under the umbrella of seronegative spondyloarthropathies. By definition, patients with these diseases do not have circulating rheumatoid factor, hence the term seronegative.23

Reactive arthritis. Involvement of knee (left) and Reactive arthritis. Involvement of knee (left) and conjunctivitis (right). Courtesy of Paul Dieppe, BSc, MD, FRCP, FFPHM.

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