What are the mechanisms of action and pharmacokinetics of sex hormones?

Updated: Jan 28, 2020
  • Author: Juan G Ochoa, MD; Chief Editor: Selim R Benbadis, MD  more...
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Progesterone is a natural anticonvulsant that acts by increasing chloride conductance at GABA-A receptors and attenuates glutamate excitatory response. It also alters messenger RNA for glutamic acid decarboxylase (GAD) and GABA-A receptor subunits. On the other hand, estrogen acts as a proconvulsant by reducing chloride conductance and acting as an agonist at NMDA receptors in the CA1 region of the hippocampus.

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