What is the role of HIV infection in the development of euthyroid sick syndrome?

Updated: Aug 28, 2020
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Patients with asymptomatic HIV infection, or AIDS, and without opportunistic infections or hepatic dysfunction have serum T4 and T3 concentrations within the reference range. Their FTI values and free T4 concentrations also are within the reference range or are slightly low. Some patients may have slightly elevated TBG concentrations, which tend to be inversely related to the percentage of CD4 cells. Some patients may have small increases in serum TSH concentrations. Patients with AIDS complicated with Pneumocystis carinii infection or other serious infections have thyroid function alterations typical of other severe NTI.

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