What is the role of acute cold in the development of euthyroid sick syndrome?

Updated: Aug 28, 2020
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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After acute cold exposure, rats have demonstrated increased serum levels of TSH and thyroid hormone; similar changes have been more difficult to demonstrate in humans. Cold exposure is associated with increased rates of deiodination of T4 and T3, enhanced hepatic binding and biliary and fecal clearance of the iodothyronines, and increased conversion of T4 to T3. A transient increase in TSH also occurs after exposure to cold.

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