What is the role of thermal injury in the development of euthyroid sick syndrome?

Updated: Aug 28, 2020
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Patients with significant burns exhibit typical euthyroid sick profile values, ie, low T3 and FT3 with increased rT3; total T4 and free T4 levels may be slightly decreased acutely but normalize after a few days. Basal TSH secretion is unchanged.

In a study of euthyroid sick syndrome in burn patients, Gangemi et al found significantly lower FT3 and TSH levels in patients who did not survive their injuries than in those who did. [19] A significant correlation was also found between FT3 concentrations and the severity of patients' burns. However, there was no significant difference in FT4 levels between survivors and nonsurvivors. The authors suggested that assessment of FT3 levels might be used in determining prognosis in burn patients.

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