What is the mortality and morbidity associated with euthyroid sick syndrome?

Updated: Aug 28, 2020
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Mortality and morbidity depend on the underlying NTI, the severity, and, possibly, the duration of the illness. [15, 16] The magnitude of the thyroid function test result abnormalities seems to depend on the severity, rather than the type, of illness. T4 is believed to fall in proportion to severity of illness.

The probability of death correlates with the levels of T4. When serum total T4 levels drop below 4 mcg/dL, the probability of death is about 50%; with serum T4 levels below 2 mcg/dL, the probability of death reaches 80%.

A study by Wang et al indicated that in high-risk patients undergoing isolated coronary artery bypass grafting (CABG), the presence of associated euthyroid sick syndrome independently increases the risk of major adverse in-hospital cardiovascular and cerebral events, the odds ratio being 3.40. The investigators also found a correlation between CABG-associated euthyroid sick syndrome and a maximum Sequential Organ Failure Assessment score of over 11. [17]

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