Which medications are used in the treatment of first adult seizure?

Updated: Nov 30, 2017
  • Author: Eissa Ibrahim AlEissa, MD, MBBS; Chief Editor: Selim R Benbadis, MD  more...
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The chosen antiepileptic drug should have high efficacy, long-term safety, good tolerability, and low interaction potential, and the agent should allow a good quality of life, especially because half of all patients never have another seizure without treatment. [8] These agents prevent seizure recurrence and terminate clinical and electrical seizure activity. [45]

The accepted principle is that one should begin with monotherapy. All newer (second-generation) agents are acceptable choices and are likely just as effective as older agents. An American Academy of Neurology (AAN) evidence-based guideline recommended lamotrigine, oxcarbazepine, topiramate, and gabapentin as appropriate for initial monotherapy; however, this guideline did not include newer antiepileptic drugs, such as levetiracetam and pregabalin.

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