What are the American Academy of Neurology (AAN) and the American Epilepsy Society (AES) treatment guidelines for first unprovoked adult seizure?

Updated: Nov 30, 2017
  • Author: Eissa Ibrahim AlEissa, MD, MBBS; Chief Editor: Selim R Benbadis, MD  more...
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Answer

In 2015,the American Academy of Neurology (AAN) and the American Epilepsy Society (AES) released a new guideline on the prognosis and treatment of first unprovoked seizures. [42, 43]

According to the guideline, immediate antiepileptic drug (AED) therapy, as compared with delay of treatment pending a second seizure, is likely to reduce recurrence risk within the first 2 years but may not improve quality of life. Clinicians’ recommendations whether to initiate immediate AED treatment after a first seizure should be based on individualized assessments that weigh the risk of recurrence against the AEs of AED therapy and that consider educated patient preferences. Patients should be advised that risk of AED adverse events (AEs) may range from 7-31% and that these AEs are likely predominantly mild and reversible. [42, 43]


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