Which medications in the drug class Antidiabetics, Long-Acting Insulins are used in the treatment of Type 2 Diabetes Mellitus?

Updated: Sep 27, 2021
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Antidiabetics, Long-Acting Insulins

These insulins provide a longer duration of action, and, when combined with rapid- or short-acting insulins, they provide better glucose control.

Insulin detemir (Levemir)

Insulin detemir is indicated for once- or twice-daily dosing in patients with type 1 or 2 diabetes mellitus. The duration of action is up to 24 hours, the result of slow systemic absorption of detemir from the injection site.

Insulin glargine (Lantus, Lantus SoloStar, Toujeo, Toujeo Max, Basaglar)

Insulin glargine stimulates proper utilization of glucose by the cells and reduces blood sugar levels. It has no pronounced peaks of action, because a small amount of insulin is gradually released at a constant rate over 24 hours. The amount of insulin in Toujeo and Toujeo Max is three times greater (300 Units/mL) than in Lantus or Basaglar (100 Units/mL).

Insulin degludec (Tresiba)

Ultralong-acting basal insulin indicated to improve glycemic control in adults with diabetes mellitus who require basal insulin. It is highly protein bound, and following SC, the protein-binding provides a depot effect. The elimination half-life is 25 h and its duration of action is beyond 42 h.

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