Which histologic findings are characteristic of facioscapulohumeral dystrophy (FSHD)?

Updated: Mar 19, 2019
  • Author: Naganand Sripathi, MD; Chief Editor: Amy Kao, MD  more...
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See the list below:

  • Muscle

    • Multifocal distribution

    • Fiber size variation with central nuclei

    • Endomysial connective tissue proliferation

    • Regenerating, moth-eaten fibers and muscle fibers undergoing phagocytosis

    • Isolated angular atrophic fibers

    • Rimmed vacuoles

    • Focal inflammation in perivascular and perimysial distributions

    • Muscle fibers expressing membrane attack complex

    • Muscle fibers expressing class 1 major histocompatibility antigen

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