What are the nonneuropathic pain symptoms of Charcot-Marie-Tooth (CMT) disease?

Updated: Feb 19, 2019
  • Author: Francisco de Assis Aquino Gondim, MD, PhD, MSc, FAAN; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Patients often have multiple nonneuropathic pain symptoms. Pain can result from pressure or strain of various structures associated with bones, joints, and tendons and abnormal posture at the knees, hips, and back, resulting from foot weakness and fixed foot deformities such as Achilles tendon shortening. Because of hammertoes and high arches, patients experience painful calluses. Scoliosis is common and leads to back pain. Patients experience leg and hand cramps that are often worse with fatigue and relieved by wearing ankle-foot orthoses. [14] The following paragraphs focus on distinguishing features of CMT subtypes.

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