Which medications in the drug class Skeletal muscle relaxants are used in the treatment of Primary Lateral Sclerosis?

Updated: Sep 06, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Nicholas Lorenzo, MD, MHCM, CPE, FAAPL  more...
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Skeletal muscle relaxants

These agents are used to treat reversible spasticity associated with MS or spinal cord lesions and are useful also in patients with spasticity due to PLS. Individual responses vary.

Baclofen (Lioresal, Gablofen)

This agent may induce hyperpolarization of afferent terminals and inhibit monosynaptic and polysynaptic reflexes at the spinal level.

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