Which medications in the drug class Benzodiazepines are used in the treatment of Primary Lateral Sclerosis?

Updated: Sep 06, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Nicholas Lorenzo, MD, MHCM, CPE, FAAPL  more...
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Answer

Benzodiazepines

These agents may act in the spinal cord to induce muscle relaxation.

Diazepam (Valium)

Diazepam depresses all levels of the central nervous system (eg, limbic and reticular formation), possibly by increasing activity of gamma-aminobutyric acid (GABA). Individualize the dosage and increase it cautiously to avoid adverse effects.

Clonazepam (Klonopin)

Clonazepam is a long-acting benzodiazepine that increases presynaptic GABA inhibition and reduces the monosynaptic and polysynaptic reflexes. It suppresses muscle contractions by facilitating inhibitory GABA neurotransmission and other inhibitory transmitters.


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