What is the role of genetic testing in the workup of primary lateral sclerosis (PLS)?

Updated: Sep 06, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Nicholas Lorenzo, MD, MHCM, CPE, FAAPL  more...
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Answer

Genetic testing for HSP may be considered if the presentation and family history suggest the condition. Confirmation of a diagnosis of HSP results in an expectation for slower disease progression and a more limited range of clinical involvement, and affects management of the patient. Appropriate genetic counseling should be offered to patients with suspected HSP before they are referred for genetic testing.


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