What is the role of motor evoked potentials in the workup of primary lateral sclerosis (PLS)?

Updated: Sep 06, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Nicholas Lorenzo, MD, MHCM, CPE, FAAPL  more...
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Motor evoked potentials may show abnormalities of the upper motor neurons, but this test is not readily available in many centers.

Lower extremity somatosensory evoked potentials occasionally show prolonged latencies in patients with primary lateral sclerosis (PLS), in the absence of sensory symptoms. This subclinical involvement of central sensory axons suggests that in those patients, the disease pathophysiology is not restricted to upper motor neurons but instead affects them preferentially.

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