What is the role of repeat electrodiagnostic testing in the workup of primary lateral sclerosis (PLS)?

Updated: Sep 06, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Nicholas Lorenzo, MD, MHCM, CPE, FAAPL  more...
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Repeat electrodiagnostic testing occasionally is considered to determine whether lower motor neurons are involved.

As overall activity diminishes, muscle atrophy may suggest lower motor neuron involvement. Such changes may be distinguished from muscle atrophy due to disuse secondary to upper motor neuron impairment on clinical grounds (eg, no fasciculations) and, more definitively, by electrophysiologic testing. Occasionally, sparse, scattered, nonprogressive changes of denervation (ie, fibrillation potentials) may be seen in distal muscles.

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