What is the role of lab testing in the workup of primary lateral sclerosis (PLS)?

Updated: Sep 06, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Nicholas Lorenzo, MD, MHCM, CPE, FAAPL  more...
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Laboratory studies for primary lateral sclerosis (PLS) should include hemogram, erythrocyte sedimentation rate, vitamin B-12 level, and, as indicated, Venereal Disease Research Laboratory (VDRL) (or rapid plasma reagent [RPR]), Lyme, HIV-1/HIV-2, and HTLV-1 serology tests.

Cerebrospinal fluid (CSF) analysis should include protein and glucose concentrations, cell count, and an MS panel. [12]

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