Which physical findings are characteristic of primary lateral sclerosis (PLS)?

Updated: Sep 06, 2019
  • Author: Carmel Armon, MD, MSc, MHS; Chief Editor: Nicholas Lorenzo, MD, MHCM, CPE, FAAPL  more...
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Signs of upper motor neuron dysfunction may include limb and trunk spasticity, pathologic spread of deep tendon reflexes, clonus, pathologic reflexes (such as Babinski sign), and spastic dysarthria.

Signs of involvement of other systems should not be present. In particular, no cerebellar findings, involuntary movements, sensory findings, findings suggesting lower motor neuron dysfunction (such as fasciculations), visual findings, or bladder dysfunction should be observed.

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