Which medications in the drug class Monoclonal Antibodies are used in the treatment of Myasthenia Gravis?

Updated: Aug 27, 2018
  • Author: Abbas A Jowkar, MBBS; Chief Editor: Nicholas Lorenzo, MD, CPE, MHCM, FAAPL  more...
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Answer

Monoclonal Antibodies

Monoclonal antibodies are used to bind to one specific substance in the body (eg, molecules, antigens). This binding is very versatile and can mimic, block, or cause changes to enact precise mechanisms (eg, bridging molecules, replacing or activating enzymes or cofactors, immune system stimulation).

Rituximab (Rituxan)

Rituximab is a genetically engineered chimeric murine-human monoclonal antibody (mAb) directed against the CD20 antigen found on the surfaces of normal and malignant B cells. The antibody is an IgG1κ immunoglobulin containing murine light- and heavy-chain variable region sequences and human constant region sequences. Risk of progressive multifocal leukoencephalopathy associated with use.

Eculizumab (Soliris)

Eculizumab is a complement inhibitor. Its precise mechanism in gMG patients is unknown, but is presumed to involve reduction of terminal complement complex C5b-9 deposition at the neuromuscular junction. It is indicated for the treatment of generalized myasthenia gravis in adults who are anti-acetylcholine receptor (AchR) antibody-positive.


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