What are the advantages and disadvantages of IV immune globulin (IVIg) in the treatment of myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas A Jowkar, MBBS; Chief Editor: Nicholas Lorenzo, MD, CPE, MHCM, FAAPL  more...
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Advantages: Noninvasive.  Pretreatment with NS 250 mL; Tylenol and Benadryl can mitigate complications.

Disadvantages:  Risk of hypersensitivity with IgA deficiency (should check IgA levels before starting), aseptic meningitis, headache, chills, myalgias, transient hypertension, fluid overload, acute tubular necrosis, hyperviscosity syndrome (stroke, MI, cryoglobulinemia, monoclonal gammopathy, high lipoproteins, or preexisting vascular disease).  Benefits last only a few weeks.

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