Which histologic findings are characteristic of myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas A Jowkar, MBBS; Chief Editor: Nicholas Lorenzo, MD, CPE, MHCM, FAAPL  more...
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Routine histopathology is not part of the evaluation of myasthenia gravis.

Routine light microscopy reveal mild, nonspecific abnormalities on muscle biopsy including type 1 fiber predominance, mild fiber type grouping, or type 2 fiber atrophy. [52]  Studies of muscle biopsy specimens showed that the NMJs of patients with MG had only one third as many AChRs as average normal individuals. Morphologic changes, such as simplification of the pattern of postsynaptic membrane folding and an increase in the gap between the nerve terminal and the postsynaptic muscle membrane, also are present.

Lymphofollicular hyperplasia of thymic medulla occurs in 65% of patients with MG and thymoma occurs in 15%.

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