What is the role of edrophonium in the evaluation of myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas A Jowkar, MBBS; Chief Editor: Nicholas Lorenzo, MD, CPE, MHCM, FAAPL  more...
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Edrophonium is being used in combination with the Lancaster red-green screen testing for diplopia. Most patients would show an improvement in some fields of gaze and a worsening in other directions of gaze. Other patients would not appreciate any change.

The combination of edrophonium with electronystagmographic analysis of optokinetic nystagmus, seems promising for the diagnosis of ocular MG. [39, 40]

Many patients receiving edrophonium besides sinus bradycardia may complain of fasciculations, borborygmi, flatus, eructations, nausea, vomiting, increased lacrimation, and in extreme cases syncope as a result of bradycardia and transient heart block.

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