Which medications in the drug class Antitubercular Agents are used in the treatment of Aseptic Meningitis?

Updated: Jul 17, 2018
  • Author: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Antitubercular Agents

These agents are used in the management of mycobacterial disease in combination with other antitubercular agents.

Rifampin (Rifadin)

Rifampin is used in combination with other antituberculous drugs. It inhibits DNA-dependent bacterial, but not mammalian, RNA polymerase. Cross-resistance may occur

Isoniazid

Isoniazid is a first-line antituberculous drug that is used in combination with other antituberculous drugs to treat meningitis. It is usually administered for at least 12-24 months. A prophylactic dose of pyridoxine (6-50 mg/day) is recommended if peripheral neuropathies secondary to isoniazid therapy develop.

Pyrazinamide

Pyrazinamide is a pyrazine analog of nicotinamide; it may be bacteriostatic or bactericidal against M tuberculosis, depending on the drug concentration attained at the site of infection. Pyrazinamide's mechanism of action is unknown.


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