How is Vogt-Koyanagi-Harada syndrome diagnosed?

Updated: Jul 17, 2018
  • Author: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Diagnosis of Vogt-Koyanagi-Harada syndrome

Typically, this syndrome affects dark-skinned individuals or those of Asian races. Symptoms consist of impaired vision, headache, tinnitus, impaired hearing, photophobia, vertigo, vomiting, and seizures. Findings include alopecia, cavities, vitiligo, iridocyclitis, uveitis, and serous retinal detachments. Occasionally, elevated protein and pleocytosis have been found in the CSF.

The disease usually occurs in the third decade of life and follows a recurrent course. Many neurological manifestations are believed to be secondary to adhesive arachnoiditis. Cranial nerve palsies and hemipareses may result. Confusion, psychosis, and seizures also have been reported.

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