How are the complications of CNS cryptococcosis treated in HIV infection?

Updated: Jan 08, 2020
  • Author: Felicia J Gliksman, DO, MPH; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Answer

In the presence of cryptococcal immune reconstitution inflammatory syndrome (IRIS) ART and antifungal therapy should be continued.

Seizures should be treated with standard therapy. Drugs that are less likely to affect bioavailability of highly active antiretroviral therapy (HAART) agents or anticryptococcal therapy are preferred.

Cognitive impairment may improve with successful anticryptococcal therapy. On a case-by-case basis, the presence of a cryptococcoma may lead to consideration of surgical intervention.

Rare visual loss due to local arachnoiditis or cryptococcal invasion of the nerves can be approached by nerve sheath decompression.


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