Which clinical history findings are characteristic of HIV-associated vacuolar myelopathy (VM)?

Updated: May 07, 2018
  • Author: Krupa Pandey, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Vacuolar myelopathy (VM) typically presents as a posterolateral spinal cord syndrome often limited to the thoracic cord. It manifests as a slowly progressive, painless spastic paraperesis with sensory loss, imbalance, and sphincter dysfunction. Relapsing-remitting courses have been described. [3]

Back pain is not prominent. Arm function is usually normal except for advanced cases.

VM is often associated with AIDS dementia complex and peripheral neuropathy. In such cases, patients have cognitive decline and distal limb pain and numbness.

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