What is the role of T SPECT and FDG PET scans in the evaluation of CNS complications in HIV infection?

Updated: Apr 12, 2018
  • Author: Regina Krel, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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If imaging shows one or more focal mass lesions without impending herniation, additional studies are warranted. When available, thallium-201 single-photon emission computed tomography (201 T SPECT) or 18-fluorodeoxyglucose positron emission tomography (18 FDG-PET) scan in conjunction with polymerase chain reaction (PCR) studies of the cerebrospinal fluid (CSF) for Epstein-Barr virus can provide strong evidence that a mass lesion represents a lymphoma. This may reduce the need for a stereotactic biopsy.

When these studies cannot be conducted, toxoplasmosis serology in conjunction with imaging results will determine how to proceed.

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