What is the risk of death in patients with Addison disease after diagnosis and treatment, and what is the risk of cardiovascular disease?

Updated: Mar 11, 2020
  • Author: George T Griffing, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Even after diagnosis and treatment, the risk of death is more than 2-fold higher in patients with Addison disease. Cardiovascular, malignant, and infectious diseases are responsible for the higher mortality rate. [8]

A study by Skov et al indicated that females with autoimmune Addison disease are at increased risk of ischemic heart disease, with an adjusted hazard ratio (aHR) of 2.15 compared with controls. The aHR in males, however, was just 1.16. In women, but not in men, higher glucocorticoid and mineralocorticoid replacement doses were independently correlated cardiovascular disease risk. The investigators found that overall in patients with autoimmune Addison disease, there were 10.7 events of first cardiovascular disease/1000 person-years, compared with 7.0 events/1000 person-years in controls. [9]

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