What is the role of angiography in the workup of cerebral amyloid angiopathy (CAA)?

Updated: Dec 19, 2018
  • Author: Ravi S Menon, MD; Chief Editor: Helmi L Lutsep, MD  more...
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Angiographic findings are abnormal only in rare cases of cerebral amyloid angiography (CAA) ̶ related vasculitis. Specificity and positive predictive value in such cases is less than 30%.

Given that some of the features of CAA and vasculitis are similar, a high index of suspicion is required. Angiography should be considered in patients with a history of hemorrhages or ischemic strokes with rapid cognitive decline (over weeks or a few months), prominent headaches, and seizures.

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