What is the role of apolipoprotein studies in the workup of cerebral amyloid angiopathy (CAA)?

Updated: Dec 19, 2018
  • Author: Ravi S Menon, MD; Chief Editor: Helmi L Lutsep, MD  more...
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The severity of cerebral amyloid angiopathy (CAA) is associated with ApoE polymorphism. The APOE gene’s e4 and e2 alleles are risk factors for CAA. The e2 allele also confers an increased risk of intracranial hemorrhage (ICH) in patients with CAA. The APOE e4 allele is associated with earlier onset of first hemorrhage and carries a significant risk of concomitant Alzheimer disease (AD). [9] Patients with lobar ICH and the e2 or e4 allele have a greater risk of early recurrence.

These tests lack sensitivity and specificity and are not indicated as screening or diagnostic procedures. However, they may be helpful prognostic tools in identifying patients with a greater risk of early recurrence.

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