What is the role of lab tests in the workup of cerebral amyloid angiopathy (CAA)?

Updated: Dec 19, 2018
  • Author: Ravi S Menon, MD; Chief Editor: Helmi L Lutsep, MD  more...
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No specific laboratory findings are diagnostic of cerebral amyloid angiopathy (CAA). However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.

Genetic evaluation can be considered, especially in patients with a family history of CAA. In cases of CAA-related ICH, laboratory studies should rule out other possible etiologies.

With regard to electroencephalography, electroencephalograms (EEGs) may be diffusely abnormal, but they usually do not show evidence of seizure focus.

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