What is the role of antiepileptic drugs in the treatment of primary central nervous system lymphoma (PCNSL)?

Updated: Jul 06, 2021
  • Author: Caroline T Goldin, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Prophylactic use of antiepileptic drugs (AEDs) should be avoided and their use should be confined to patients who experience seizures. Any of the first-line AEDs (eg, phenytoin, carbamazepine, valproic acid) would be appropriate for patients with PCNSL, although leukopenia and liver function abnormalities from any of these drugs potentially could be confused with chemotherapy-related toxic effects. New-generation antiepileptic drugs, such as levetiracetam (Keppra), have high efficacy and fewer side effects.

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