What is the role of brain biopsy in the workup of primary central nervous system lymphoma (PCNSL)?

Updated: Jul 06, 2021
  • Author: Caroline T Goldin, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Stereotactic brain biopsy is the most appropriate method for the diagnosis of PCNSL. However, open brain biopsy may be necessary in those patients who have lesions located in areas of the brain that are difficult to access (eg, brainstem). If possible, the procedure should be performed before corticosteroids have been administered.

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