Which medications in the drug class Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are used in the treatment of CNS Lupus?

Updated: May 04, 2021
  • Author: Pradeep C Bollu, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

These agents provide symptomatic relief for arthralgias, fever, and mild serositis. NSAIDs may cause elevated liver function test results in patients with active lupus. Additionally, concomitant administration with prednisone may increase the risk of GI ulceration.

Ibuprofen (Advil, Motrin IB, Addaprin, IBU-200, NeoProfen)

Ibuprofen is the drug of choice for patients with mild-to-moderate pain. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Naproxen (Anaprox, Naprelan, Naprosyn)

Naproxen is used for relief of mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing the activity of the enzyme cyclooxygenase, resulting in prostaglandin synthesis.


Ketoprofen is used for the relief of mild-to-moderate pain and inflammation. Small doses are initially indicated in small and elderly patients and in those with renal or liver disease. Doses >75 mg do not increase therapeutic effects. Administer high doses with caution, and closely observe patient for response.

Diclofenac (Voltaren XR, Cataflam, Cambia, Zipsor, Zorvolex)

Diclofenac inhibits prostaglandin synthesis by decreasing the activity of the enzyme cyclo-oxygenase, which in turn reduces the formation of prostaglandin precursors.

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