Which drugs are being investigated for the treatment of CNS lupus?

Updated: May 04, 2021
  • Author: Pradeep C Bollu, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

mycophenolate-343209">Mycophenolate mofetil is an effective and safer alternative to cyclophosphamide for patients with lupus nephritis. Other therapeutic approaches under development include anticytokine therapies, costimulatory blockade, antigen-specific immune modulation, and hematopoietic stem cell transplantation. [46]

Epratuzumab, a monoclonal antibody against the B-cell surface antigen CD22, and atacicept, a chimeric molecule formed by a receptor for B-cell–activating factor and a proliferation-inducing ligand with immunoglobulin G (IgG), have both been promising in initial small trials; larger clinical trials are under way. [47] Clinical trial data have shown that B-cell targeting therapies are beginning to fulfill their promise as treatments for systemic lupus erythematosus (SLE), and there are good reasons to hope for further progress in the near future.


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