What is the role of EEG in the workup of CNS lupus?

Updated: May 04, 2021
  • Author: Pradeep C Bollu, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Electroencephalography (EEG) may be helpful to confirm the focal point of an apparently diffuse encephalopathy in patients with systemic lupus erythematosus (SLE). This study is most useful in patients with seizures whose cases are difficult to manage.

EEG also provides a measure of recurrence risk when anticonvulsant therapy is withdrawn. An active spike focus (especially with multiple loci), frequent discharges, or localization to the frontotemporal region predicts a likely recurrence of seizures after anticonvulsant cessation.

A normal EE.G., even with sleep deprivation, does not exclude the possibility of recurrent seizures. It generally is associated with a reduced recurrence risk, although this has not been studied specifically in central nervous system (CNS) lupus.

Reported selective left temporolimbic region changes [40] are not always observed.

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