How is fatigue characterized in patients with CNS lupus?

Updated: May 04, 2021
  • Author: Pradeep C Bollu, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Chronic fatigue is a common symptom in SLE and usually does not relate to objective muscular effort (i.e., walking up stairs may seem no harder than walking on level ground). [20] Fatigue may contribute to both self-perceived and to measurable cognitive impairment, chiefly by impairing frontal lobe attentional functions. This may relate to metabolic dysfunction of brain parenchyma, as discussed in Organic Encephalopathies.

Depression, myopathy, excessive daytime fatigue due to nocturnal sleep disorder, and systemic conditions (e.g., electrolyte disturbance, fluid overload, pulmonary insufficiency) remain in the differential diagnosis. Many patients with mild orthostatic hypotension present with symptoms resembling chronic fatigue and may not complain of the usual presyncopal symptoms.

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