What is the prognosis of CNS lupus?

Updated: May 04, 2021
  • Author: Pradeep C Bollu, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Central nervous system (CNS)-specific statistics are not available, however, neuropsychiatric events in systemic lupus erythematosus (SLE) have a more favorable outcome than events secondary to non-SLE causes. Events attributed to SLE generally occur during the early course of the illness, do have a negative impact on the quality of life of the patient, and do vary in severity and frequency. [5]

Neurologic complications worsen prognosis, especially in the presence of refractory seizures, encephalopathy, or paralysis from stroke or myelopathy.

Taddio et al concluded that presence of atypical manifestations of pediatric SLE at presentation and early kidney disease correlated with poor outcome. Similarly, during follow-up, kidney and CNS diseases were associated with worse outcome. [12]

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